Treatment Treatment of non-Hodgkin’s lymphoma depends on the state of the disease, the type of cells involved, if it is aggressive or indolent and the age and general health status of the patient. NHL is often treated by a team of specialists that may include a hematologist, medical oncologist and a radiologist specialist in oncology. Usually treatment includes chemotherapy, radiotherapy, immunotherapy or a combination of treatments. In some cases bone marrow transplantation, biological therapies, or surgery may be options. For indolent lymphomas, can be expected to begin treatment until the disease symptoms. Often, this situation is called the “watchful waiting”. Taking part in clinical trials (research) to evaluate new ways to treat disease is an important option for many people who have it.Chemotherapy and radiotherapy are the most common treatments for NHL, although bone marrow transplantation, biological therapies and surgery are sometimes used. The most common combination chemotherapy is the use of the drug group known as CHOP (cyclophosphamide, adriamycin, vincristine and prednisone) with rituximab added in certain cases. Radiation therapy using high-energy radiation to kill cancer cells. The radiation treatment can be done alone or with chemotherapy. Radiotherapy is a local treatment that affects cancer cells only in the treated area. Radiation therapy for non-Hodgkin lymphoma is made with a team that runs the high-energy rays to a specific area of the body. There is radioactivity in the body when treatment is finished. The radio-immunotherapy is a combination of immunological agents (such as Rituximab) with radioactive isotopes, and offers some benefits in treating localized tumors at the molecular level.Sometimes patients receive chemotherapy or radiation therapy to kill undetected cancer cells that may be present in the central nervous system (CNS). In this treatment, called central nervous system prophylaxis, the doctor injects anticancer drugs directly into the cerebrospinal fluid. Bone marrow transplantation may also be a treatment option, especially in patients whose non-Hodgkin lymphoma has suffered a relapse (has recurred). The bone marrow transplant provides the patient with healthy cells of shock (very immature cells that produce blood cells) to replace cells damaged or destroyed by high doses of chemotherapy or radiotherapy. The healthy bone marrow may come from a donor, or even the patient of which was obtained previously, treated to destroy cancer cells, stored, and returned to the patient after treatment at high doses.Until the transplanted bone marrow begins to produce enough white blood cells, patients must be carefully protected to avoid infections. Usually, they stay in the hospital for several weeks and then in environments with low probability of infection (clean homes, away from crowds, without traveling on airplanes …). Biological therapy (also called immunotherapy) is a form of treatment that uses the body’s immune system, directly or indirectly, to fight cancer or to lessen side effects that some cancer treatments can produce. Use elements generated by the body or made in the laboratory to boost, direct, or restore the body’s natural defenses against disease. Biological therapy is sometimes the therapy called biological response modifier.